Codeine is claimed to indicate no proof of carcinogenicity or mutagenicity in many different take a look at systems, such as the micronucleus and sperm abnormality assays plus the Salmonella assay. Promethazine was nonmutagenic from the Salmonella examination system of Ames.The 1 scenario in which CYP2D6 ultra-speedy metabolizer status was reported